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High Assay Rivastigmine Tartrate Medical Raw Materials Cas 129101-54-8

Guangzhou Huao Chemical Co.,Ltd
Guangzhou Huao Chemical Co.,Ltd
City: Guangzhou
Province/State: Guangdong
Country/Region: China
Tel: 86-188-26120470
Contact Person:
Mr Adam

High Assay Rivastigmine Tartrate Medical Raw Materials Cas 129101-54-8

Brand Name : Guangzhou Huao
Model Number : 129101-54-8
Certification : IOS9001 ,Kosher, COA,SGS,USP
Place of Origin : Guangzhou China
MOQ : 10g
Price : Negotiation
Payment Terms : T/T, Western Union,Paypal, MoneyGram,Bitcoin,Bank Transfer
Supply Ability : 1000kg/month
Delivery Time : 4-7 days
Packaging Details : Foil Bag or Tin, Perfect Discreet, as Required
Assay : >99%
transport packing : Foil Bag or Tin, Perfect Discreet, as Required
Reship Policy : Reship Free
samples : Available
Appearance : white crystalline powder
E-mail : evan@ycphar.com
Whatsapp : +8615622635381
Market : Global
Contact Now

High Assay Rivastigmine Tartrate Medical Raw Materials Cas 129101-54-8


English Name: Rivastigmine tartrate
English synonyms: RIVASTIGMINE TARTRATE SALT; Rivastigmine tartrate; SDZ-ENA 713; SDZ-ENA 713; Ethylmethyl-carbamic Acid 3-[(1S) -1- (Dimethylamino) ethyl]phenyl Ester, Bitartrate; RIVASTIGIMINETARTRATE (FORR&DONLY); (S) -N-Ethyl-3-[(1-dimethylamino) ethyl]-N-methylphenylcarbamate hydrogen tartrate; Rivastigmine tartrate; Rivastigmine-d6 tartarate
CAS: 129101-54-8
Molecular formula: C18H28N2O8
Molecular weight: 400.42


pharmacological action:


Tartaric acid tartrate in Kabbala for the Kabbala Ting Ting drugs for the treatment of Alzheimer's disease, Kabbala Ting as physostigmine derivatives by Novartis company successfully developed the first commercial name, Exelon (Exelon), phenyl carbamate with molecular structure, is a kind of amino acid selective cerebral cholinesterase inhibitor, at the same time the inhibition of acetylcholinesterase and butyrylcholinesterase, by delaying degradation of cholinergic neurons and promote the release of acetylcholine in cholinergic nerve conduction, can improve the cognitive dysfunction of cholinergic mediated, so as to improve the cognitive function of patients with Alzheimer's disease.


The plasma protein binding capacity of Kabbala Ting is weak and it is easy to pass through the blood-brain barrier (BBB) with high brain selectivity. It not only selectively acts on the most vulnerable areas of the cerebral cortex and hippocampus, but also preferentially inhibits the dominant subtypes of AChE in the brain, which can reduce peripheral cholinergic side effects while producing efficacy. The tartrate Kabbala Ting has a short half-life in vivo and a long acting time. Unlike his sodium chloride, this product inhibits G1 in the hippocampus and cortex. Clinically used in the treatment of mild to moderate Alzheimer's dementia, known as Alzheimer's disease or Alzheimer's disease.



Matters needing attention:


1. as an ache inhibitor, Kabbala tartrate can increase the action of succinylcholine. Therefore, there should be a suitable interval before anesthesia to stop taking this product. This product is particularly careful with other cholinergic or anticholinergic agents (see "drug interaction").



2. because of their pharmacological effects, cholinesterase inhibitors may have an vagal effect on heart rate. Like other cholinergic drugs, patients who have been given sinus syndrome or other heart block have to be very careful (see adverse reactions).


3. cholinergic nerve stimulation can cause increased gastric acid secretion. Although no corresponding symptoms were found evidence of clinical deterioration during the probation period, high risk of gastric ulcer patients, like those with ulcer disease, or non steroidal anti-inflammatory drugs with the treatment of patients, should be used with caution.



4., as with other cholinesterase inhibitors, patients with asthma history or other obstructive pulmonary diseases should be treated with caution Kabbala tartrate.



COA

Appearance

A white to off-white hygroscopic crystalline powder

Identification

Should conform

Solubility

Should conform

Specefic Rotation

+10°~+14°(in 5mg/ml of water)

Water

NMT3.0%

Heavy Metals

NMT0.002%

Limit of Free Phosphate

NMT0.1%

Limit of Sodium

NMT0.2%

Limit of chloride

NMT0.2%

Microbial Limits Test

Should conform

Related substances

Should conform

Residual Solvents

should conform

Assay

98.0%~102.0%


Drug interaction:


(1) the Kabbala tartrate is mainly hydrolyzed by cholinesterase, and the isozyme of cytochrome P450 is seldom involved in metabolism. Therefore, there is no pharmacokinetic interaction between this product and other drugs that are metabolizing these enzymes.



(2) in healthy volunteers, no pharmacokinetic interaction was observed between digoxin and Hua Falin, diazepam or fluoxetine (3mg). Prolonged prothrombin time induced by Hua Falin is not affected by this product. Digoxin was not found to have an adverse effect on cardiac conduction after coadministration with this product.



(3) in clinical studies in patients with Alzheimer's disease, this product with some commonly used prescription drugs combined application, such as antacids, antiemetic drugs, antidiabetic drugs, beta blockers, calcium channel blockers, inotropic drugs, anti angina drugs, non steroidal anti-inflammatory drugs, estrogen, painkillers, diazepam, antihistamines, not with an increased risk of clinically relevant adverse reactions.



(4) given the pharmacokinetic effects of this product, this product should not be used in combination with other anticholinergic agents, and it may interfere with the activity of anticholinergic agents.



(5) there is no experience of this product in combination with anti Parkinson drugs, anti anxiety drugs (except diazepam), antipsychotic drugs, anti epileptic drugs and antidepressant drugs.



(6) Kabbala tartrate, a cholinesterase inhibitor, can enhance the action of succinylcholine in anesthesia.



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CAS: 314728-85-3

2

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3

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4

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5

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6

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7

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8

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9

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10

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11

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CAS:123441-03-2

12

Entacapone

CAS:130929-57-6

13

Oxiracetam

CAS:62613-82-5

14

Aniracetam

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15

Donepezil

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16

brivaracetam

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17

Etiracetam

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18

Raubasine

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19

Rivastigmine tartrate

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20

Fladrafinil

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