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Guangzhou Huao Chemical Co.,Ltd
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Estrogen Suppression Supplements Letrazole Powder For Breast Cancer 112809-51-5

Estrogen Suppression Supplements Letrazole Powder For Breast Cancer 112809-51-5

Brand Name : Guangzhou Huao
Model Number : 112809-51-5
Certification : IOS9001 ,Kosher, COA,SGS,USP
Place of Origin : Guangzhou China
MOQ : 10g
Price : Negotiation
Payment Terms : T/T, Western Union,Paypal, MoneyGram,Bitcoin,Bank Transfer
Supply Ability : 1000kg/month
Delivery Time : 4-7 days
Packaging Details : Foil Bag or Tin, Perfect Discreet, as Required
Assay : >99%
transport packing : Foil Bag or Tin, Perfect Discreet, as Required
Reship Policy : Reship Free
samples : Available
Appearance : white crystalline powder
E-mail : evan@ycphar.com
Whatsapp : +8615622635381
Market : Global
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Anti Estrogen Steroids Letrazole Powder For Breast Cancer 112809-51-5
English Name: Letrozole
English synonyms: 4,4'- (1H-1,2,4-TRIAZOL-1-YLMETHYLENE) BIS-BENZONITRILE; FEMARA; CGS-20267; LETROZOL; LETROZOLE;; LetrozoleUsp28; Letrozole99%; CGS-20267; Femara
CAS: 112809-51-5
Molecular formula: C17H11N5
Molecular weight: 285.3
Related categories: anti breast cancer; Aromatics; Heterocycles; pharmaceutical raw materials; ELOXATIN; anti-cancer drugs; Anti-cancer&immunity; small molecule inhibitors; small molecule inhibitors; natural products
Usage:Pyrrolidine type enzyme inhibitor. Used in the treatment of breast cancer.
pharmacological action

1.)Letrozole is a new generation of highly selective aromatase inhibitors, is a synthesis of benzyl three triazole derivatives, through inhibition of aromatase, the estrogen levels decline, thereby eliminating the stimulating effect of estrogen on tumor growth. The activity in vivo is 150-250 times stronger than that of the first generation aromatase inhibitor ammonia. Due to its high selectivity, no influence of glucocorticoid and mineralocorticoid and thyroid function, the use of large dose of corticosteroid substances secretion had no inhibitory effect, so it has a higher therapeutic index. The research shows that pre clinical, letrozole has no potential toxicity to the systemic and target organ, non mutagenic and carcinogenic effects and less toxicity, well tolerated, and compared to other aromatase inhibitors and anti estrogen drugs, stronger antitumor effect. It is suitable for the treatment of advanced breast cancer, postmenopausal patients and early treatment of breast cancer which is not effective in the treatment of estrogen.

2.)In December 2005 the UK medicines and healthcare products regulatory approval of letrozole Novartis company (Fu Long) was used for the treatment of breast cancer patients, allows it to use after surgical treatment, early postmenopausal hormone positive invasive breast cancer patients. This is the second in June 2005 second aromatase inhibitors are approved in the UK after the approval of AstraZeneca arimidex. In clinical trials of two drugs showed that the risk can better prevent breast cancer recurrence and current treatment compared to standard tamoxifen.

The difference between Letrozol Tablets and anastrozole
Letrozol Tablets: suitable for advanced breast cancer in postmenopausal women, for the treatment of anti estrogen second-line treatment failure after treatment.

Anastrozole: three azole a potent selective aromatase inhibitors, it can inhibit the cytochrome P-450 dependent aromatase thereby blocking the biosynthesis of estrogen, estrogen and the main factors for stimulating the growth of breast cancer cells. The product of the human placental aromatase 50% inhibition concentration (IC50) value of 15nmol / L.

Adverse reactions and side effects

The randomized trial showed that the incidence of adverse effects associated with oral letrozole 2.5mg was 33%, which was significantly lower than 46% in the AG group. The adverse reaction to letrozole is mild or moderate, with nausea (2% ~ 9%), headache (0% ~ 7%), pain (4% ~ 10%), hot flashes (0% ~ 9%) and weight (2% ~ 8%) as the main performance, other rare and constipation, diarrhea, rash, itching, joint pain, chest pain, abdominal pain, fatigue, insomnia, dizziness, edema, hypertension, arrhythmia, thrombosis, dyspnea, vaginal bleeding, etc.
Production methods
4- methyl cyanide (I) and three triazole were reacted in chloroform acetonitrile, and the product (II) was re reacted with 4-, which was reacted with two methyl formamide in the presence of tert butyl alcohol, which was called letrozole.

Product Tags:

estrogen blocking supplements

      

estrogen suppression supplements

      
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