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Guangzhou Huao Chemical Co.,Ltd
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07868-30-4 Anti Estrogen Steroids Exemestane Powder Aromasin For Breast Cancer

07868-30-4 Anti Estrogen Steroids Exemestane Powder Aromasin For Breast Cancer

Brand Name : Guangzhou Huao
Model Number : 107868-30-4
Certification : IOS9001 ,Kosher, COA,SGS,USP
Place of Origin : Guangzhou China
MOQ : 10g
Price : Negotiation
Payment Terms : T/T, Western Union,Paypal, MoneyGram,Bitcoin,Bank Transfer
Supply Ability : 1000kg/month
Delivery Time : 4-7 days
Packaging Details : Foil Bag or Tin, Perfect Discreet, as Required
Assay : >99%
transport packing : Foil Bag or Tin, Perfect Discreet, as Required
Reship Policy : Reship Free
samples : Available
Appearance : white crystalline powder
E-mail : evan@ycphar.com
Whatsapp : +8615622635381
Market : Global
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Anti Estrogen Steroids Exemestane Powder Aromasin For Breast Cancer
NameExemestane
CAS number07868-30-4
MFC20H24O2
MW296.4
English synonyms6-methylenandrosta-1,4-diene-3,17-dione; 6-METHYLENEANDROSTA-1,4-DIENE-3,17-DIONE; 10,13-dimethyl-6-methylidene-7,8,9,10,11,12,13,14,15,16-decahydrocyclopenta[a]phenanthrene-; EXEMESTANE; FCE-24304; AROMASIN; Exemestan;

Summary
Exemestane is an irreversible steroidal aromatase inhibitor, substrate structure and natural androst-4-ene-3,17-dione in two similar. Through the inhibition of aromatase to estrogen deprivation is an effective and alternative method for treatment of postmenopausal women with hormone dependent breast cancer, for after tamoxifen treatment, the disease has not yet in natural or artificial postmenopausal women with advanced breast cancer.

Function and use
Exemestane is steroidal aromatase inactivator, natural substrate androstenedione and the structure of the two similar to aromatase, pseudo aromatase substrate. Because postmenopausal women estrogen is mainly composed of androgen (adrenal cortex produced) generated from the aromatase role in peripheral tissues, this product with the active site of aromatase irreversible binding to inactivation, thereby significantly reducing the postmenopausal women blood circulating estrogen levels. This product has no obvious effect on adrenal cortex hormone biosynthesis, even if the concentration is higher than the concentration of aromatase inhibiting 600 times, in other ways of generating the cortical hormone enzyme had no significant effect.

The product was orally absorbed rapidly, absorbed by food, and oral bioavailability was 42%. The rate of drug absorption in postmenopausal women was higher than that in healthy subjects, and the peak concentration of serum reached 2~4 hours after oral administration, and the peak time was 1.2 hours, which was shorter than that of healthy subjects (2.9 hours). It mainly binds to alpha 1- acid glycoprotein and protein, and the binding rate of total protein is 90%. Mainly by the liver metabolism, the metabolic activity of 17- without hydrogen exemestane, elimination half-life of 24 hours. Excreted mainly by urine or feces, each accounted for 42% of the dose.

Adverse reaction

The main adverse effects of this product are nausea, dry mouth, constipation, diarrhea, dizziness, insomnia, skin rash, fatigue, fever, swelling, pain, vomiting, abdominal pain, increased appetite, weight gain and so on. Secondly, there are hypertension, depression, anxiety, dyspnea, cough and so on in the literature. Others include decreased lymphocyte counts, abnormalities of liver function (such as alanine aminotransferase), etc..

purpose
Pharmaceutical raw material, as a kind of irreversible steroidal aromatase inactivator can inhibit the synthesis of estrogen, estrogen decrease in blood circulation, apply to menopause after tamoxifen treatment after disease progression in patients with advanced breast cancer

Dosage
One 25mg, 1 times a day, after meals, oral. There is no need to adjust the dosage of the patients with mild liver or kidney dysfunction.

Product Tags:

estrogen blocking supplements

      

estrogen suppression supplements

      
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