Anti Estrogen Steroids Tamoxifen Citrate Powder Nolvadex for men
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|English Name||Tamoxifen citrate|
citrate; (z) -2- (4- (1,2-diphenyl-1-butenyl) phenoxy) -n,
|Related categories||antineoplastic drugs, antitumor drugs and immunosuppressive agents;
antibiotics; raw materials; small molecule inhibitors; Inhibitors;
small molecule inhibitors; natural products; antineoplastic|
know more about Tamoxifen Citrate
Tamoxifen citrate (tamoxifen, tamoxifen citrat e, referred to as
TCT), is a kind of estrogen (estrogen) antagonists, non steroid
anti estrogen drugs in vivo, and estrogen (estradiol) competition,
combined with estrogen receptor in breast cancer cells, thereby
inhibiting the effect of estrogen on cancer cells and tumor cell
growth retardation, and anti-cancer effects. Clinically, it is
commonly used in the treatment of various types of breast cancer,
especially for postmenopausal women with low estrogen receptor and
progesterone receptor and low prostate specific antigen levels.
Mechanism of action
TCT has CIS trans isomer, and its cis isomer shows weak estrogen
effect, whereas trans isomer has anti estrogen effect. When
tamoxifen was used early or at low concentrations, it was combined
with estrogen receptor (ER) in the cytoplasm, thus showing a weak
estrogen effect. When TCT enters the nucleus, it inhibits the
transcription and synthesis of nuclear ER and produces long-lasting
anti estrogen effects. Many new functions of TCT have been found to
be related to the mechanism of action, the membrane regulation
mechanism, that competes beyond estrogen receptors. TCT, as a
membrane regulator, can reduce cell circulation. On the basis of
this, it can also be used as an antioxidant to protect cell
membranes and human LDL from oxidative damage.
1. breast cancer treatment.
2. prevention of breast cancer.
3. antitumor and multidrug resistance.
Tamoxifen citrate by reducing membrane circulation and enhance cell
binding site between the rigid, cancer transfer promoter and
various activating enzyme concentration and activity decreased, so
as to inhibit or prevent cancer cell growth and metastasis. In
addition, it can also promote the secretion of tumor cells around
the negative growth factor transforming growth factor TGF- G, curb
unlimited reproduction and can inhibit cancer cells; produced by
human neutrophils caused by H2O2 DN A base oxidation damage, so the
other malignant tumors of breast cancer treatment and beyond are
the benefits of prevention, has been applied to brain tumor, liver
cancer, prostate cancer and other cancer treatment. In addition,
tamoxifen citrate can reduce the release of P170 glycoprotein on
the cell membrane by reducing the membrane mobility, and improve
the effective concentration of cytotoxic drugs in cells and reduce
4. heart protection.
The overview, mechanisms, and clinical applications of tamoxifen
citrate were edited by Chemicalbook's Ding Hong editor.
Common nausea, vomiting, facial flushing and other minor adverse