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Guangzhou Huao Chemical Co.,Ltd
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Local Anesthetics Drugs Lidocaine Hydrochloride Lidocaine HCL For Pain Killer

Guangzhou Huao Chemical Co.,Ltd
Guangzhou Huao Chemical Co.,Ltd
City: Guangzhou
Province/State: Guangdong
Country/Region: China
Tel: 86-188-26120470
Contact Person:Mr Adam

Local Anesthetics Drugs Lidocaine Hydrochloride Lidocaine HCL For Pain Killer

Brand Name : Guangzhou Huao
Model Number : 6108-05-0
Certification : IOS9001 ,Kosher, COA,SGS,USP
Place of Origin : Guangzhou China
MOQ : 10g
Price : Negotiation
Payment Terms : T/T, Western Union,Paypal, MoneyGram,Bitcoin,Bank Transfer
Supply Ability : 1000kg/month
Delivery Time : 4-7 days
Packaging Details : Foil Bag or Tin, Perfect Discreet, as Required
Assay : >99%
transport packing : Foil Bag or Tin, Perfect Discreet, as Required
Reship Policy : Reship Free
samples : Available
Appearance : white crystalline powder
E-mail : evan@ycphar.com
Whatsapp : +8615622635381
Market : Global
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Local Anesthetic Powder Lidocaine Hydrochloride Lidocaine HCL for pain killer

Lidocaine HCL simple details

CAS73-78-9
NameLidocaine hydrochloride
Molecular formulaC14H23ClN2O
Molecular weight270.8
EINECS200-803-8
Physical and chemical propertiesWhite crystalline, odorless, slightly bitter taste and hemp. Highly soluble in water, ethanol and organic solvents, but not soluble in ether. The water solution does not decompose under acid or alkali conditions, repeated autoclaving and very little spoilage.
UsageA local anesthetic, an antiarrhythmic drug, used in various forms of anesthesia and rapid ventricular arrhythmias

Local anesthetics and antiarrhythmic drugs
Because of local anesthetic and anti arrhythmic drugs. Clinically, it is mainly used for infiltration anesthesia, epidural anesthesia, surface anesthesia (including mucosal anesthesia during thoracoscopy or abdominal surgery) and nerve block. It can also be used for ventricular premature beats and ventricular tachycardia after acute myocardial infarction, and can also be used for digitalis intoxication, cardiac surgery and ventricular arrhythmias induced by cardiac catheterization. But it is usually ineffective for supraventricular arrhythmias.

Acetanilide hydrochloride because of local anesthetic of amide group. After the absorption of blood or intravenous administration, there was biphasic excitatory and inhibitory effects on the central nervous system, and no precursor excited, blood concentration is low, analgesic and sleepiness, pain threshold increased; with the dose increase, enhancing effect or toxicity, has anticonvulsant effects of sub toxic blood concentration; when the blood concentration of more than 5 mu g ml-1 convulsions may occur. Lidocaine hydrochloride at low doses, can promote myocardial intracellular K+ outflow, reduce myocardial and self-discipline, has antiarrhythmic effect; in therapeutic doses, had no significant effect on the electrical activity of myocardial cells, the atrioventricular and myocardial contraction; blood concentration further increased, can cause cardiac conduction slow down, atrioventricular block, inhibition of myocardial contractility and cardiac output decreased.

Function and use
Lidocaine hydrochloride has the characteristics of penetrating, strong dispersion and quick onset. The anesthetic efficacy is 2 times and procaine, and the toxicity is 1. 5 minutes after the use of drugs can be anesthetic effect, anesthesia for 1 to 1.5 hours, 50% longer than procaine. After absorption can inhibit the central nervous system, and can inhibit ventricular automaticity, shorten the refractory period, can be used to control ventricular tachycardia, therapeutic room premature beat, ventricular tachycardia and ventricular fibrillation symptoms. It is effective for arrhythmia caused by heart disease or cardiac glycosides, but it is not effective for supraventricular tachycardia. This product is fast, short duration, ineffective oral administration, often as intravenous injection.

Adverse reaction
The adverse reaction rate of lidocaine hydrochloride is about 6.3%. The majority of adverse reactions were related to dosage. The adverse reactions were dizziness, drowsiness, dizziness, nausea, vomiting, fatigue, euphoria, mental disorder, muscle cramps, convulsions, blurred vision, unconsciousness and breathing difficulties, large doses can produce severe sinus bradycardia, cardiac arrest, reduce severe atrioventricular block and cardiac contractility, blood pressure decline. Lidocaine hydrochloride in serum is too high, which can cause slow atrial conduction, atrioventricular block (A-V-B), and decrease cardiac contractility and cardiac output. A small number of allergic reactions, such as erythema, rash and vascular edema.

Matters needing attention
(1) allergic to other local anesthetics may also be allergic to lidocaine hydrochloride.
(2) the following conditions are carefully used: pregnant women, newborns, especially premature infants, lower hepatic blood flow, liver and kidney dysfunction, congestive heart failure, severe myocardial damage, low blood volume and shock.
(3) strictly grasp the concentration and total amount of medication, excessive can cause convulsions and cardiac arrest; its metabolism in vivo is slower than procaine, has accumulation effect, can cause poisoning and convulsions.
(4) the dosage should be adjusted according to the needs and the degree of tolerance of the elderly. The dosage should be halved in patients over 70 years old.
(5) prevent the obstruction of blood vessel during anesthesia and prevent the local anesthetic poisoning.
(6) the treatment of arrhythmia should pay attention to monitoring blood pressure and electrocardiogram, and equipped with rescue equipment; electrocardiogram P-R prolongation or QRS is wide, the emergence of other arrhythmias or original arrhythmia aggravation shall immediately stop.
(7) anesthesia electrocardiogram P-R prolongation or QRS is wide, the emergence of other arrhythmias or original arrhythmia aggravation shall immediately stop.
Dosage
For surface anaesthesia, use 2% - 5% solution. For infiltration anesthesia, 0.25% ~ 0.5% solution. Conduction anaesthesia with 2% hydrochloride solution, each injection point, horse, cow 8~12 ml, sheep 3~4 ml. Epidural anesthesia 2% solution, horse, cow 8~12 ml, dog and cat weight per kilogram of 0.22 ml.. Subcutaneous injection with 2% solution, maximal, pig, sheep, cattle, horse 80 ml, 400 ml, 25 ml and 8.5 ml of dogs and cats.
To treat arrhythmia, intravenous injection: initial dose of 2~4 mg per kilogram body weight, followed by intravenous drip of 25~75 micrograms per minute, cat initial dose of 250~500 micrograms, followed by intravenous drip of 20 micrograms per minute.

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