Local Anesthetic Powder Lidocaine Hydrochloride Lidocaine HCL for
Lidocaine HCL simple details
|Physical and chemical properties||White crystalline, odorless, slightly bitter taste and hemp. Highly
soluble in water, ethanol and organic solvents, but not soluble in
ether. The water solution does not decompose under acid or alkali
conditions, repeated autoclaving and very little spoilage.|
|Usage||A local anesthetic, an antiarrhythmic drug, used in various forms
of anesthesia and rapid ventricular arrhythmias|
Local anesthetics and antiarrhythmic drugs
Because of local anesthetic and anti arrhythmic drugs. Clinically,
it is mainly used for infiltration anesthesia, epidural anesthesia,
surface anesthesia (including mucosal anesthesia during
thoracoscopy or abdominal surgery) and nerve block. It can also be
used for ventricular premature beats and ventricular tachycardia
after acute myocardial infarction, and can also be used for
digitalis intoxication, cardiac surgery and ventricular arrhythmias
induced by cardiac catheterization. But it is usually ineffective
for supraventricular arrhythmias.
Acetanilide hydrochloride because of local anesthetic of amide
group. After the absorption of blood or intravenous administration,
there was biphasic excitatory and inhibitory effects on the central
nervous system, and no precursor excited, blood concentration is
low, analgesic and sleepiness, pain threshold increased; with the
dose increase, enhancing effect or toxicity, has anticonvulsant
effects of sub toxic blood concentration; when the blood
concentration of more than 5 mu g ml-1 convulsions may occur.
Lidocaine hydrochloride at low doses, can promote myocardial
intracellular K+ outflow, reduce myocardial and self-discipline,
has antiarrhythmic effect; in therapeutic doses, had no significant
effect on the electrical activity of myocardial cells, the
atrioventricular and myocardial contraction; blood concentration
further increased, can cause cardiac conduction slow down,
atrioventricular block, inhibition of myocardial contractility and
cardiac output decreased.
Function and use
Lidocaine hydrochloride has the characteristics of penetrating,
strong dispersion and quick onset. The anesthetic efficacy is 2
times and procaine, and the toxicity is 1. 5 minutes after the use
of drugs can be anesthetic effect, anesthesia for 1 to 1.5 hours,
50% longer than procaine. After absorption can inhibit the central
nervous system, and can inhibit ventricular automaticity, shorten
the refractory period, can be used to control ventricular
tachycardia, therapeutic room premature beat, ventricular
tachycardia and ventricular fibrillation symptoms. It is effective
for arrhythmia caused by heart disease or cardiac glycosides, but
it is not effective for supraventricular tachycardia. This product
is fast, short duration, ineffective oral administration, often as
The adverse reaction rate of lidocaine hydrochloride is about 6.3%.
The majority of adverse reactions were related to dosage. The
adverse reactions were dizziness, drowsiness, dizziness, nausea,
vomiting, fatigue, euphoria, mental disorder, muscle cramps,
convulsions, blurred vision, unconsciousness and breathing
difficulties, large doses can produce severe sinus bradycardia,
cardiac arrest, reduce severe atrioventricular block and cardiac
contractility, blood pressure decline. Lidocaine hydrochloride in
serum is too high, which can cause slow atrial conduction,
atrioventricular block (A-V-B), and decrease cardiac contractility
and cardiac output. A small number of allergic reactions, such as
erythema, rash and vascular edema.
Matters needing attention
(1) allergic to other local anesthetics may also be allergic to
(2) the following conditions are carefully used: pregnant women,
newborns, especially premature infants, lower hepatic blood flow,
liver and kidney dysfunction, congestive heart failure, severe
myocardial damage, low blood volume and shock.
(3) strictly grasp the concentration and total amount of
medication, excessive can cause convulsions and cardiac arrest; its
metabolism in vivo is slower than procaine, has accumulation
effect, can cause poisoning and convulsions.
(4) the dosage should be adjusted according to the needs and the
degree of tolerance of the elderly. The dosage should be halved in
patients over 70 years old.
(5) prevent the obstruction of blood vessel during anesthesia and
prevent the local anesthetic poisoning.
(6) the treatment of arrhythmia should pay attention to monitoring
blood pressure and electrocardiogram, and equipped with rescue
equipment; electrocardiogram P-R prolongation or QRS is wide, the
emergence of other arrhythmias or original arrhythmia aggravation
shall immediately stop.
(7) anesthesia electrocardiogram P-R prolongation or QRS is wide,
the emergence of other arrhythmias or original arrhythmia
aggravation shall immediately stop.
For surface anaesthesia, use 2% - 5% solution. For infiltration
anesthesia, 0.25% ~ 0.5% solution. Conduction anaesthesia with 2%
hydrochloride solution, each injection point, horse, cow 8~12 ml,
sheep 3~4 ml. Epidural anesthesia 2% solution, horse, cow 8~12 ml,
dog and cat weight per kilogram of 0.22 ml.. Subcutaneous injection
with 2% solution, maximal, pig, sheep, cattle, horse 80 ml, 400 ml,
25 ml and 8.5 ml of dogs and cats.
To treat arrhythmia, intravenous injection: initial dose of 2~4 mg
per kilogram body weight, followed by intravenous drip of 25~75
micrograms per minute, cat initial dose of 250~500 micrograms,
followed by intravenous drip of 20 micrograms per minute.