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For Female Health Anti Estrogen Steroids Powder Ethynyl Estradiol 57-63-6

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City: Guangzhou
Province/State: Guangdong
Country/Region: China
Tel: 86-188-26120470
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For Female Health Anti Estrogen Steroids Powder Ethynyl Estradiol 57-63-6

Brand Name : Guangzhou Huao
Model Number : 57-63-6
Certification : IOS9001 ,Kosher, COA,SGS,USP
Place of Origin : Guangzhou China
MOQ : 10g
Price : Negotiation
Payment Terms : T/T, Western Union,Paypal, MoneyGram,Bitcoin,Bank Transfer
Supply Ability : 1000kg/month
Delivery Time : 4-7 days
Packaging Details : Foil Bag or Tin, Perfect Discreet, as Required
Assay : >99%
transport packing : Foil Bag or Tin, Perfect Discreet, as Required
Reship Policy : Reship Free
samples : Available
Appearance : white crystalline powder
E-mail : evan@ycphar.com
Whatsapp : +8615622635381
Market : Global
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Anti Estrogen Steroids Powder ethynyl estradiol 57-63-6 for Female Health


The Description of ethynyl estradiol

CAS:57-63-6

Ethynyl estradiol
EINECS:200-342-2
General Description:Fine white to creamy white powder. A synthetic steroid. Used in combination with
progestogen as an oral contraceptive.

MF:C20H24O2
MW:296.4


Ethynyl estradiol Medical uses
As Estinyl, EE2 was formerly used for hormone replacement therapy in menopause and the treatment of female hypogonadism, loss of menstruation, dysmenorrhea, acne, prostate type of cancer, and breast cancers.

However, in additional recent times, EE2 is especially used in COCs. In contraception, because of concerns of unopposed estrogen action along with the possible increased likelihood of endometrial cancer that accompanies this, EE2 is formulated together with progestins. EE2 is little utilized in menopausal hrt


Ethynyl estradiol INFO:

Ethinyl Estradiol is hormonally effective by activating the estrogen receptor and thus is an estrogen . It finds its most common use in the estrogen-progestin combination preparations of oral contraceptives .
Ethinyl Estradiol is absorbed within the small intestine and reaches a serum peak around 2 hours later . It undergoes extensive metabolism within the liver regarding the cytochrome P450 3A4 isoenzyme . Ethinyl Estradiol and its metabolites are excreted with all the bile . Due to the effect of enterohepatic circulation an additional peak is observed several hours later . Individually , wide variations appear in the overall absorption process , and could be further modified by drugs that affect the enterohepatic circulation or liver enzymes . In circulation Ethinyl Estradiol is nearly fully guaranteed to plasma albumin . It really is metabolized by hydroxylation with the aromatic ring and excreted in feces and urine , to some extent as glucuronide and sulfate conjugate .

Interactions
Inducers of certain cytochrome P450 enzymes such as CYP3A4 can decrease circulating concentrations of EE2. Examples include anticonvulsants like phenytoin, primidone, ethosuximide, phenobarbital, and carbamazepine, azole antifungals like fluconazole, and rifamycin antibiotics like rifampin and rifampicin. Conversely, inhibitors of CYP3A4 and certain other cytochrome P450 enzymes may increase circulating amounts of EE2. An example is troleandomycin, the industry potent and highly selective inhibitor of CYP3A4.

Paracetamol has been seen as to competitively inhibit the sulfation of EE2, with pretreatment of 1 g paracetamol significantly improving the AUC levels of EE2 (by 22%) and lowering the AUC levels of EE2 sulfate in females. The same has been seen for vitamin c (vitamin C) and EE2, although the significance in the interaction has been regarded as dubious.
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whatsapp:+8615622635381
Skype live:1537611728
E-mail:evan@ycphar.com


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