Product Name: Altrenogest
Chemical Properties: Pale Yellow Solid
Usage A synthetic progestational agent used in veterinary medicine
for the control of estrus in mares.
|Items of analysis||Specification||Results|
|Appearance||Alomost white or light yellow crystalline||conforms|
|Loss on Drying||≤0.50%||0.08%|
|Related foreign steroids||≤2%||conform|
Description And Applications Of Altrenogest:
The pharmacodynamic activity of altrenogest has been demonstrated
in a number of animal models. The most important effects are the
progestomimetic and anti-gonadotrophic effects. Altrenogest also
has weak oestrogenic, anabolic and androgenic effects, but has no
corticoid or anti-inflammatory effects.
Altrenogest is indicated to suppress estrus in mares to allow a
more predictable occurrence of estrus following withdrawal of the
It is used clinically to assist mares to establish normal cycles
during the transitional period from anestrus to the normal breeding
season often in conjunction with an artificial photoperiod. It is
more effective in assisting in pregnancy attainment later in the
transition period. One group of authors (Squires et al. 1983)
suggest selecting mares with considerable follicular activity
(mares with one or more follicles 20 mm or greater in size) for
treatment during the transitional phase. Mares that have been in
estrus for 10 days or more and have active ovaries are also
considered to be excellent candidates for progestin treatment.
Altrenogest is effective in normally cycling mares for minimizing
the necessity for estrus detection, for the synchronization of
estrus and permitting scheduled breeding.
Estrus will ensue 2-5 days after treatment is completed and most
mares ovulate between 8-15 days after withdrawal. Altrenogest is
also effective in suppressing estrus expression in show mares or
mares to be raced. Although the drug is labeled as contraindicated
during pregnancy, it has been demonstrated to maintain pregnancy in
oophorectomized mares and may be of benefit in mares who abort due
to sub-therapeutic progestin levels.
Altrenogest Powder Dosage:
In veterinary medicine, altrenogest is used in gilts and mares for
zootechnical purposes (oestrus synchronization). The recommended
dose for gilts is 20 mg/animal/day given orally for 18 consecutive
days, and for mares is 0.044 mg/kg bw/day given orally for 10 to 15
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