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CAS 13647-35-3 Anti Estrogen Steroids Trilostane Powder for Breast Cancer

CAS 13647-35-3 Anti Estrogen Steroids Trilostane Powder for Breast Cancer

Brand Name : Guangzhou Huao
Model Number : 13647-35-3
Certification : IOS9001 ,Kosher, COA,SGS,USP
Place of Origin : Guangzhou China
MOQ : 10g
Price : Negotiation
Payment Terms : T/T, Western Union,Paypal, MoneyGram,Bitcoin,Bank Transfer
Supply Ability : 1000kg/month
Delivery Time : 4-7 days
Packaging Details : Foil Bag or Tin, Perfect Discreet, as Required
Assay : >99%
transport packing : Foil Bag or Tin, Perfect Discreet, as Required
Reship Policy : Reship Free
samples : Available
Appearance : white crystalline powder
E-mail : evan@ycphar.com
Whatsapp : +8615622635381
Market : Global
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Anti Estrogen Steroids Trilostane Powder for Breast Cancer Treatment 13647-35-3

  • Usage : Trilostane can inhibit cortical hormone in the process of synthesis of 3 beta dehydrogenase, make the cortisol, aldosterone synthesis decreased, clinically used in the treatment of Cushing syndrome (hypercortisolism) and primary aldosteronism. This product also had significantly effect to decreased serum testosterone level.
  • Trilostane
  • Synonym: Vetoryl
  • CAS :13647-35-3
  • Alias:99%
  • Einecs No:237-133-0
  • Grade : Pharmaceutical Grade
  • Storage: Shading, confined preservation
  • Appearance:: White crystalline powder


Trilostane Info

Trilostane blocks an enzyme active in the production of several steroide including cortisol. Inhibiting this enzyme inhibits producing cortisol. In Cushing's syndrome, the adrenal gland overproduces steroide. Although steroide are crucial for various functions with the body, too much can cause problems. Trilostane decreases the amount of steroide made by the adrenal gland.
Test ItemsSpecificationTest Results
Appearancewhite oralmost white,crystalline powderConform
SolubilityFreely soluble in water,practically insoluble or very slightly
soluble in alcohol and in methylene chloride.
Conform
IdentificationAThe UV absorption spectrum of the sample shows
an absorption maximum at 276nm.The specific
absorbance at the Maximum is55 to 64.
Conform
BInfraed absorption spectrophotometry.Conform
CChromatogram obtained with test solution (b) is
similar in position color & size to the principal spot in the
chromatogram obtained with the reference solution.
Conform
DAn orange-red color develop in methylene chloride layer.Conform
EIt geves reaction (a) of sulphates.Conform
Appearance of solutionSolution S is clear and not more intensely coloured than
reference solution in BY6.
Conform
Optical rotationnegative 0.10° to +0.10°determined on solution S.+0.01°
Acidity or alkalinityNMT 0.4ml of 0.01M HCL is required to change the color
of the indicator to red.
Conform
Related substancesImpurity J ≤0.20%Conform
Any other impurity ≤0.30%Conform
Total impurity ≤1.0%Conform
Boron≤50ppmConform
Sulphated ash≤0.10%0.06%
Loss on drying≤0.5%0.30%
Assay(on dried basis)98.0~101.0%99.5%

Trilostane Applications:

Trilostane is utilized in the treating Cushing's syndrome. It can be normally used in short-term treatment until permanent care is possible.
Trilostane blocks an enzyme mixed up in production of several steroids including cortisol. Inhibiting this enzyme inhibits making cortisol. In Cushing's syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions with the body, excessive can cause problems. Trilostane cuts down on the amount of steroids made by the adrenal gland.

Trilostane produces suppression from the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.
Side effect:Symptoms of overdose include darkening of skin, drowsiness or tiredness, loss of appetite, mental depression, skin rash, and/or vomiting.

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CAS 13647-35-3 Anti Estrogen Steroids Trilostane Powder for Breast Cancer Images

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