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94-15-5 Local Anesthetic Powder Dimethocaine / Larocaine for Pain release

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94-15-5 Local Anesthetic Powder Dimethocaine / Larocaine for Pain release

Brand Name : Guangzhou Huao
Model Number : 94-15-5
Certification : IOS9001 ,Kosher, COA,SGS,USP
Place of Origin : Guangzhou China
MOQ : 10g
Price : Negotiation
Payment Terms : T/T, Western Union,Paypal, MoneyGram,Bitcoin,Bank Transfer
Supply Ability : 1000kg/month
Delivery Time : 4-7 days
Packaging Details : Foil Bag or Tin, Perfect Discreet, as Required
Assay : >99%
transport packing : Foil Bag or Tin, Perfect Discreet, as Required
Reship Policy : Reship Free
samples : Available
Appearance : white crystalline powder
E-mail : evan@ycphar.com
Whatsapp : +8615622635381
Market : Global
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Local Anesthetic Powder Dimethocaine/ Larocaine for Pain release 94-15-5


Dimethocaine/ Larocaine CAS number:94-15-5

Purity: 99%

packaging information: 100g, 1kg, 25kg

Mp 53.0 to 57.0 ° C
The density is 1.035
Merck 14,3221
InChIKey OWQIUQKMMPDHQQ-UHFFFAOYSA-N

Usage: Strong anesthetics, and some people also use Dimethocaine for undefined uses



What is Dimethocaine ?


1.Dimethocaine is also a well-known narcotic powder in the world, especially in the United States and the United Kingdom. There are many Brazilian friends who have purchased cocaine repeatedly from our company.


2.Dimethocaine, a synthetic derivative of cocaine, is widely used as a new psychoactive substance with "Victory is Justice", however, without any safety testing such as case studies of drug metabolism. The aim of this work was therefore to study its in vivo and in vitro metabolism by using liquid chromatography (high resolution) mass spectrometry (LC-HRMSn). Dimethocaine (20 mg / kg) was administered to Wistar rats and urine metabolites were extracted by enzymatic cleavage of the conjugate by solid-phase extraction or by protein precipitation. LC-HRMS was used to separate and identify metabolites. The main phase Ⅰ reaction is ester hydrolysis, de-ethyl, aromatic ring hydroxylation reaction. The major phase II reaction is the acetylation of p-aminobenzoic acid and several phase I metabolites N-in the parent compound. Metabolite identification was used to identify diclazine in rat urine following the usual dose. Dimethocaine and its metabolites can be detected by standard urinalysis using GC-MS and LC-MS.


COA:

Applicatoin:

1. Dimethocaine (DMC, cocaine, 3-diethylamino-2,2-dimethylpropyl) -4-aminobenzoate was used as a local anesthetic for dentistry and ophthalmology in the 1930s, Dopamine reuptake inhibitors, like cocaine, have an excitatory effect and therefore can not circulate freely in the market because it has these psychic effects. In the meantime, DMC has drawn the attention of the global drug industry as a substitute for legal cocaine, just as the so-called "new psychoactive substance" (NPS). It even ranks among the "synthetic cocaine derivatives" category of the European drug and drug addiction monitoring center and is also available in numerous online stores. After consuming Dimethocaine, consumers have a pleasant feeling, but also complaints of dyspnea and angina.


2. Pharmacological properties of Dimethocaine and cocaine in vivo after intraperitoneal injection in rats. Dopamine (DA) levels and its metabolites were measured. Research shows that Dimethocaine increases dopamine concentration in the nucleus accumbens by stimulating the reward system. Woodward et al., Suggesting that DMC is similarly potent as cocaine in inhibiting dopamine reuptake. Wilcox et al. Compared the pharmacological properties of different local anesthetics, concluded that the order of inhibition of dopamine uptake by different drugs was: Cocaine> Dimethocaine> Tetracaine> Procaine>


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Product Tags:

local anesthetic agents

      

local anesthetics drugs

      
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94-15-5 Local Anesthetic Powder Dimethocaine / Larocaine for Pain release Images

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