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CAS 97240-79-4 Pharmaceutical Raw Materials Topiramate Powder

CAS 97240-79-4 Pharmaceutical Raw Materials Topiramate Powder

Brand Name : Huao(Whatsapp:+8615622635381)
Model Number : 97240-79-4
Certification : IOS9001 ,Kosher, COA,SGS,USP
Place of Origin : Guangzhou China
MOQ : 10g
Price : Negotiation
Payment Terms : T/T, Western Union,Paypal, MoneyGram,Bitcoin,Bank Transfer
Supply Ability : 1000kg/month
Delivery Time : 4-7 days
Packaging Details : Foil Bag or Tin, Perfect Discreet, as Required
Assay : >99%
transport packing : Foil Bag or Tin, Perfect Discreet, as Required
Reship Policy : Reship Free
samples : Available
Appearance : white crystalline powder
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Whatsapp : +8615622635381
Market : Global
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Pharmaceutical Raw Materials Topiramate Powder CAS 97240-79-4

CAS: 97240-79-4
MF: C12H21NO8S
MW: 339.36

Synonyms: 2,3:4,5-bis-o-(1-methylethylidene)-beta-d-fructopyranossulfamate;MCN 4853;2,3:4,5-BIS-O-(1-METHYLETHYLIDENE)-36-D-FRUCTO-PYRANOSE SULFAMATE;2,3:4,5-BIS-O-(1-METHYLETHYLIDENE)-B-D-FUCTO-PYRANOSE SULFAMATE;2,3:4,5-bis-o-(1-methylethylidene)-beta-d-fructopyranose sulfamate;2,3:4,5-BIS-O-(1-METHYLETHYLIDENE)-BETA-D-FUCTOPYRANOSE SULFAMATE;RWJ 17021;RWJ-17021-000

Topiramate Introduction:

Topiramate (TPM), also known as Tuo Tai, Topei Feng Te, Toumou Mai, is a natural monosaccharide Quanquan dextrose fructose sulfide, and non-urethane, lamotrigine, aminobenzoic acid is the current clinical Application of more broad-spectrum antiepileptic drugs, can be used to control different types of epilepsy, efficacy and pharmacokinetics, but in children and the amount of fast can cause cognitive impairment and neurotoxicity, and easy to promote kidney stones. In 1980, scientists first synthesized topiramate in the laboratory, in 1986 for the first epilepsy patients, in 1995, the first time in the UK market. Its basic structure is pyran fructosyl sulfamate, different from other antiepileptic drugs. TPM has a variety of antiepileptic mechanisms that block voltage-dependent sodium channels, enhance GABA activity at gamma-aminobutyric acid A (GABAA) receptors, block glutamate AMPA receptor activity, and mild The role of carbonic anhydrase inhibitors. Europe and the United States double-blind, placebo-controlled study results have confirmed that topiramate additional treatment of various types of refractory epilepsy has a good effect and safety, good tolerance. Has now started with topiramate monotherapy, but also achieved good results, 62% of patients with seizures completely disappeared. This product is generally used for antiepileptic drug adjuvant therapy, simple and complex seizures and systemic tonic clonic seizures effective, can also be used for the treatment of infantile spasms. This product is characterized by long-term efficacy is good, no obvious resistance, high doses can also be used alone antiepileptic.

Topiramate Dosage

As adjunctive treatment with partial seizures accompanied by or without secondary systemic seizures. It is advisable to increase from the low dose to the effective dose. Do not break the tablet. Adults recommended the first week of service every week 50mg, 2 weeks morning and evening service 50mg, 3 weeks morning service 50mg, 100mg at night, the first 4 weeks morning and evening service 100mg, 5 weeks morning service 100mg, evening service 150mg, 6 Week morning and evening service 150mg, 7 weeks morning service 150mg, 200mg at night, 8 weeks morning and evening service 200mg. Maintenance of 400mg / d. 2 to 16 years old children recommended daily 5 ~ 9mg / kg, 2 times taking. Dose adjustment Week 1 25mg (1 ~ 3 mg / kg daily), taking at night. After every 1 to 2 weeks daily amount of 1 ~ 3mg / kg, divided into 2 times, until the best clinical results.




AppearanceWhite to off-white powder, Freely soluble in dichloromethaneWhite powder, Freely soluble in dichloromethane
IdentificationInfared AbsorptionComplies
The retention time of the major peak in the chromatogram of the Assay prepration corresponds to that in the chromatogram of the standard preparation, as obtained in the assaycomplies
Specific rotationBetween -28.6°and -35.0°, measured at 20°-32.8°
Waternot more than 0.5%0.12%
residue on ignitionnot more than 0.2%0.11%
Heavy metalsnot more than 0.001%complies
related compounds by HPLC(Test1)Fructose not more than 0.3% Compound A not more than 0.3% Other individual impurity not more than 0.1% Total impurities not more than 0.5%Fructose: 0.03%
Compound A:0.04%individual impurity Total impurities: 0.07%
Particle size90% less than 350 micronscomplies
Limit of sulfamate and sulfateSulfamate ion not more than 0.10% Sulfate ion not more than 0.10%complies
Residual SolventMethylene Chloride not more than 250μg/gnot detected
Acetone not mor than 2500μg/g
Isopropanol not more than 5000μg/g
Ethanenitrile not more than 400μg/g
n-hexane not more than 290μg/g
Ethyl Acetate not more than 2500μg/g
Pyridine not more than 100μg/g
AssayTopiramate contains not less than 98.0% and not more than the equivalent of 102.0% of C12H21NO8S, calculated with reference to the Anhydrous Basis99.80%
ConclustionThe material complies with respect to USP35

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